| 기술분야 |
○ Molecular mechanism of neuro-degeneration diseases (Alzheimer""s disease) ○ Molecular & cellular carcinogenesis and chemoprevention |
| 산업협력분야 |
-신경계질환(치매치료제 개발기술 보유, 항우울증 개발 기술 및 물질보유) -관절염치료제 개발 기술 및 물질 보유 -항암제 개발 기술 보유 -항당뇨비만개발 기술 및 물질 보유 -안전성약리 평가 기술 보유 |
| 연구실적 |
○ 총 논문 129 건 등재 ○ 총 특허 16 건 등록 6건 출원 |
| 논문 |
○ Jin Tae Hong et al. (2004). Antiarthritic effect of bee venom: inhibition of inflammation mediator generation by suppression of NF-kappaB through interaction with the p50 subunit. Arthritis Rheum. 50 (11), 3504-15. ○ Jin Tae Hong et al. (2005). The role of nitric oxide on glutaminergic modulation of dopaminergic activation. Pharmacol Res. 52 (4), 298-301. ○ Jin Tae Hong et al. (2006). PS2 mutation increases neuronal cell vulnerability to neurotoxicants through activation of caspase-3 by enhancing of ryanodine receptor-mediated calcium release. FASEB J. 20 (1), 151-3. ○ Jin Tae Hong et al. (2007). Therapeutic application of anti-arthritis, pain-releasing, and anti-cancer effects of bee venom and its constituent compounds. Pharmacol Ther. 115 (2), 246-70. ○ Jin Tae Hong et al. (2008). Growth inhibitory effects of obovatol through induction of apoptotic cell death in prostate and colon cancer by blocking of NF-kappaB. Eur J Pharmacol. 582 (1-3), 17-25. ○ Jin Tae Hong et al. (2009). Inflexinol inhibits colon cancer cell growth through inhibition of nuclear factor-kappaB activity via direct interaction with p50. Mol Cancer Ther. 8 (6), 1613-24. |
| 특허 |
○ 치아크레모논을 유효성분으로 포함하는 암의 예방 또는 치료용 약제학적 조성물 (등록번호:1009069830000) ○ 신남알데히드 유도체 화합물을 함유하는 염증성 질환의 예방 및 치료용 약학조성물 (등록번호:1006767610000) ○ 후박추출물을 함유하는 아밀로이드 관련 질환의 치료 또는 예방용 조성물 (출원번호: 1020070022430) ○ Pharmaceutical composition comprising thiacremonone for preventing or treating cancer (출원번호:12/186534) |
